{"id":15057,"date":"2021-06-07T08:56:52","date_gmt":"2021-06-07T06:56:52","guid":{"rendered":"https:\/\/convergences.online\/hemato\/?p=15057"},"modified":"2024-12-11T13:21:09","modified_gmt":"2024-12-11T12:21:09","slug":"evolution-naturelle-des-lymphocytoses-b-monoclonales","status":"publish","type":"post","link":"https:\/\/www.hematostat.net\/en\/evolution-naturelle-des-lymphocytoses-b-monoclonales\/","title":{"rendered":"\u00c9volution naturelle des lymphocytoses B monoclonales"},"content":{"rendered":"

R\u00e9f. : HematoStat.net ; 2 (2) : R16<\/p>\n

Natural history of monoclonal B-cell lymphocytosis <\/em>among relatives in CLL families<\/em><\/strong><\/p>\n

Slager, S. L. and al. Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families. Blood 137, 2046\u20132056 (2021).<\/span><\/i><\/a><\/div>\n
<\/div>\n
\n

R\u00e9sum\u00e9 :<\/strong><\/h3>\n

Il est \u00e9tabli qu\u2019une histoire familiale de leuc\u00e9mie lympho\u00efde chronique (LLC) conf\u00e8re un risque important de d\u00e9velopper une LLC. N\u00e9anmoins, la pr\u00e9valence des lymphocytoses B monoclonales (LBM) et le risque d\u2019\u00e9volution vers une LLC au sein de ces familles est mal connu. Les auteurs ont pu inclure 310 familles avec cas de LLC, 1 045 apparent\u00e9s ont b\u00e9n\u00e9fici\u00e9 d\u2019un d\u00e9pistage de LMB en cytom\u00e8trie de flux. Le suivi prospectif a concern\u00e9 449 apparent\u00e9s.<\/p>\n

Dans nos pratiques :<\/strong><\/h3>\n

Large \u00e9tude de cohorte multicentrique qui permet de mieux comprendre la pr\u00e9valence et le risque \u00e9volutif des LMB. Une d\u00e9monstration ici d\u2019un passage de LMB <0,5 G\/L \u00e0 une LLC, le taux de progression \u00e9tant \u00e9valu\u00e9 \u00e0 1,1 % par an (en exc\u00e8s par rapport \u00e0 la population g\u00e9n\u00e9rale). Pour l\u2019ensemble de la cohorte prospective, le taux d\u2019incidence cumul\u00e9 de LLC \u00e0 5 ans \u00e9tait de 1,8 % (suivi m\u00e9dian : 8,1 ann\u00e9es).<\/p>\n

Le regard du statisticien :<\/strong><\/h3>\n

L\u2019incidence de progression est calcul\u00e9e selon la m\u00e9thode de Kaplan-Meier \u2018invers\u00e9e\u2019 et non de la fonction d\u2019incidence cumul\u00e9e tenant compte des risques comp\u00e9titifs (comme le d\u00e9c\u00e8s), donc attention, les incidences calcul\u00e9es peuvent \u00eatre un peu surestim\u00e9es. Les r\u00e9sultats de l\u2019article sont globalement descriptifs et se passent bien souvent de comparaisons statistiques ou d\u2019estimations de risque. La lecture des tables n\u2019est pas forc\u00e9ment intuitive non plus.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":16,"featured_media":15058,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[36],"tags":[83,84,85,86,87],"ppma_author":[456],"class_list":["post-15057","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-revue-de-presse","tag-cytometrie-de-flux","tag-lbm","tag-llc","tag-methode-de-kaplan-meier","tag-risques-competitifs","author-alexis-genthon"],"aioseo_notices":[],"authors":[{"term_id":456,"user_id":16,"is_guest":0,"slug":"alexis-genthon","display_name":"Alexis GENTHON","avatar_url":{"url":"https:\/\/www.hematostat.net\/wp-content\/uploads\/2023\/06\/Capture-decran-2021-05-07-a-14.25.02.png","url2x":"https:\/\/www.hematostat.net\/wp-content\/uploads\/2023\/06\/Capture-decran-2021-05-07-a-14.25.02.png"},"first_name":"","last_name":"","user_url":"","description":"H\u00e9matologue.\r\nCorrespondance : H\u00f4pital Saint-Antoine \r\nService h\u00e9matologie clinique\r\n184 rue du Faubourg Saint-Antoine 75012 Paris."}],"_links":{"self":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts\/15057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/comments?post=15057"}],"version-history":[{"count":1,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts\/15057\/revisions"}],"predecessor-version":[{"id":18183,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts\/15057\/revisions\/18183"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/media?parent=15057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/categories?post=15057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/tags?post=15057"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/ppma_author?post=15057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}