{"id":15126,"date":"2021-06-10T10:54:53","date_gmt":"2021-06-10T08:54:53","guid":{"rendered":"https:\/\/convergences.online\/hemato\/?p=15126"},"modified":"2021-06-10T10:54:53","modified_gmt":"2021-06-10T08:54:53","slug":"la-mutation-hotspot-dikzf3-ikzf3-l162r-a-ete-identifiee-comme-un-moteur-putatif-de-la-llc","status":"publish","type":"post","link":"https:\/\/www.hematostat.net\/en\/la-mutation-hotspot-dikzf3-ikzf3-l162r-a-ete-identifiee-comme-un-moteur-putatif-de-la-llc\/","title":{"rendered":"La mutation hotspot d&#8217;IKZF3 (IKZF3-L162R) a \u00e9t\u00e9 identifi\u00e9e comme un moteur putatif de la LLC"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:calc( 1240px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:0px;--awb-width-medium:100%;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:0px;--awb-width-small:100%;--awb-spacing-right-small:0px;--awb-spacing-left-small:0px;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>R\u00e9f. :HematoStat.net ; 1 (1) : V6<\/p>\n<p><a href=\"https:\/\/mdanderson.elsevierpure.com\/en\/publications\/a-hotspot-mutation-in-transcription-factor-ikzf3-drives-b-cell-ne\">Lazarian G, Yin S, Ten Hacken E, Sewastianik T, Uduman M, Font-Tello A, Gohil SH, Li S, Kim E, Joyal H, Billington L, Witten E, Zheng M, Huang T, Severgnini M, Lefebvre V, Rassenti LZ, Gutierrez C, Georgopoulos K, Ott CJ, Wang L, Kipps TJ, Burger JA, Livak KJ, Neuberg DS, Baran-Marszak F, Cymbalista F, Carrasco RD, Wu CJ. A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer Cell. 2021 Mar 8;39(3):380-393.e8. doi: 10.1016\/j.ccell.2021.02.003. PMID: 33689703; PMCID:\u00a0PMC8034546.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":15129,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[11],"tags":[108,109,110],"ppma_author":[451],"class_list":["post-15126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-veille-bibliographique","tag-ikzf3","tag-modele-llc","tag-mutation-driver","author-vincent-levy"],"aioseo_notices":[],"authors":[{"term_id":451,"user_id":9,"is_guest":0,"slug":"vincent-levy","display_name":"Vincent LEVY","avatar_url":{"url":"https:\/\/www.hematostat.net\/wp-content\/uploads\/2023\/06\/Capture-decran-2021-05-07-a-13.21.23.png","url2x":"https:\/\/www.hematostat.net\/wp-content\/uploads\/2023\/06\/Capture-decran-2021-05-07-a-13.21.23.png"},"first_name":"","last_name":"","user_url":"","description":"H\u00e9matologue, PU, PH en Pharmacie Clinique. <br>\r\nResponsable de l\u2019Unit\u00e9 de Recherche Clinique et du Centre de Recherche Clinique du GH de Seine-Saint-Denis, H\u00f4pital Avicenne. <br>\r\nMembre du CA et du CS du FILO. <br>\r\n<strong>Expertise : <\/strong>Leuc\u00e9mie lympho\u00efde chronique, essais cliniques.<br>\r\n<strong>Liens d'int\u00e9r\u00eat au 01\/01\/2023: <\/strong> Abbvie, AstraZeneca, Janssen.<br>\r\n<strong>Correspondance : <\/strong>H\u00f4pital Avicenne CRC\/URC, 125 rue de Stalingrad 96000 Bobigny."}],"_links":{"self":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts\/15126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/comments?post=15126"}],"version-history":[{"count":0,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/posts\/15126\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/media?parent=15126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/categories?post=15126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/tags?post=15126"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.hematostat.net\/en\/wp-json\/wp\/v2\/ppma_author?post=15126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}